Hot flushes during menopause? It could all be GENETIC, say researchers

Hot flushes during menopause? It could all be GENETIC, say researchers

GETTYScientists discovered potential genetic factors behind hot flushesNow American researchers may have found a link between the symptoms and genetics.They have discovered gene variants that affect a receptor in the brain that regulates the release of the hormone oestrogen.Women with the variants are more likely to have hot flushes than women who lack them.GETTYThe discoveries could lead to more and better treatmentIt is hoped that the findings could lead to new treatments to help ease the women’s suffering. No previous studies have focused on how variants in women’s genes may be linked with hot flushes Professor Carolyn Crandall Professor Carolyn Crandall, of the David Geffen School of Medicine at UCLA, said: “No previous studies have focused on how variants in women’s genes may be linked with hot flushes, and these results were highly statistically significant.“These associations were similar across European-American, African-American and Hispanic-American women, and they persisted even after we accounted for other factors that might influence hot flushes.”Ethnicity has been linked to an increased risk for frequent symptoms, as have having a higher body mass index, lower education, smoking, anxiety and depression.GETTYThe results were consistent across various ethnicities Other common menopause symptoms include difficulty sleeping, a reduced sex drive and headaches.They can start a few months or years before women’s periods stop, with someone women experiencing them for another 12 years.The researchers looked at common genetic variations to find links between variations in genes and hot flushes and night sweats.They examined data from 17,695 postmenopausal women aged 50 to 79 who provided DNA samples and information about whether they had experienced hot flushes or night sweats.GETTYThe study was the first of its kind and should be replicated in the futureThe researchers examined more than 11 million gene variants, and found that 14 of them were associated with experiencing hot flushes.Prof Crandall noted that the researchers cannot determine how e…

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